1. Food Ingredients

Nano Type Chondroitin®

The molecular weight-reduced with patented technology

The ray (Rajidae) is commonly eaten in Hokkaido and Tohoku region for a long time, and Wakkanai makes up 50% of its haul in Japan. The fin part was only consumed, and all the other parts are thrown away.
The ray is a member of elasmobranchii family same as shark, and its bones are mostly configured by cartilage. We focused on these characteristics.
Research is done based on industry-academia-government collaboration to extract chondroitin sulfate from the cartilage.
Chondroitin sulfate usually consists of polysaccharide (molecular weight around 0.1 MILL to 0.15 MILL), however, we successfully lower the molecular weight of polysaccharide with 2 to 12 saccharide (molecular weight around 500 to 3,000) by using the patented technology of Micro-chemistry process manufacturing method which is invented by Hokkaido Bureau of Economy, Trade and Industry, Hokkaido Industrial Research Institute and Hokkaido University.
Because of the process, absorption rate of chondroitin into the body dramatically increase. By increasing the the quality of the ingredeint, we can reduce the dosage and cost at the same time.

Display Name Example for Food Chondroitin sulfate oligosaccharide, Low molecular chondroitin, etc.
Display Name Example for Cosmetics
Origin Raw material Ray (Rajidae)
Origin Raw material's Place of Origin Hokkaido
Manufacturing Place Hokkaido
Ingredients Chondroitin Sulfate Oligosaccharide (Low Molecular Weight Chondroitin)
Standardized Ingredients Low Molecular Weight Chondroitin Sulfate 80%
Functional Claims
Recommended Dosage 10-100mg/day (by in-house exam)
Expected Function ◎ Arthritis treatment, anti-inflammatory effect ◎ Improving locomotive syndrome ◎ Antitumor activity ◎ Improving skin function ◎ Moisturizing the skin ◎ Lipase inhibitory activity (Suppressing fat accumulation in adipocytes, anti-obesity, diet effect)
Uses ◎ Supplements, drinks and processed food for joints. ◎ Supplements, drinks and processed food for beauty and health.
Properties White to light yellow water-soluble powder
Storage Condition Keep in cool dry place, and avoid direct sunlight.
  • Healthy Do
  • Patented Technology
  • Upcycling

■ What is Nano Type Chondroitin® ?
Chondroitin sulfate is constructed by macromolecules (molecular weight of 0.1 MILL to
0.15 MILL). Glucuronic acid and N-acetylgalactosamine: minimum
unit of disaccharide bonding forms those macromolecules.
The macromolecule chondroitin sulfate which is extracted from Ray caught around Wakkanai is decomposed by antienzymatic micro-chemistry process manufacturing method. We named the decomposed chondroitin sulfate oligosaccaride as "Nano type chondroitin®".

This successive mass production process of Nano type chondroitin® is world's first cutting edge technology.


■ Impressive absorption rate of chondroitin into the body
As a result of absorption test using everted sac method of laboratry rat, absorption rate of
Nano type chondroitin® is more than 254 times as absorbable as the macromolecule chondroitin.


■ High in water solubility
Comparing Nano type chondroitin® and macromolecule chondroitin, Nano type chondroitin
dissolves easily, and prevents lumps in water, thus Nano type chondroitin is suited for the all
sorts of processing.


■ Clinical Study Data

Clinicall test is conducted with cooperation of the subjects ingested 100mg/day of Nano type chondroitin®. As a result, the JKOM score related to locomotive syndrome is improved with ingested group.


■ Improving JKOM Score
Informal test is conducted with cooperation of the osteopathic clinic. Subjects ingested 10mg/day of Nano type chondroitin®. As a result, the function evaluation scale of
patients with deformed knee arthropathy (JKOM) is improved.


■ Use of Trademark
◎"Nano-type chondroitin®" is a registered trademark in Japan.
To display the trademark on your product, the trademark
use contract is required.


■Use of Hokkaido University logo
◎The Hokkaido University logo can be displayed on your product.
Please contact us if you need it.

The information posted on this page are for engineers involved in the production of health foods and cosmetics.
Please note that this material is not intended for general consumers.